AMD is nearly crushed 20 with the rapid development of a high-tech, raw materials can increase 10% or even nano-micron powder, in all walks of life have been widely used. Given the crush of Chinese medicine production and the application of the basic processing technology, AMD has been growing crush cause for concern, although its late start, the varieties developed relatively small, but has shown a unique advantage and broad application prospects.

     1. AMD smash Technical Overview
     Ultrafine powder smash engineering technology is an important element, including ultrafine grinding powder materials, and high-precision classification changes, such as surfactants. According to the raw materials and finished particle size or size, can be divided into rough smash smash, smash the small, micro and AMD smash smash, this is a general classification. It is noteworthy that various countries and sectors, the use of superfine powder, preparation methods and different levels of technology, the size of Supermicropowder different division.
     AMD is generally no screen grinder mill to crush the material flow rate control particle size, particle size requirements to smash through the 95% 0.15mm (100 head), typically used for fish bait or fish special weaning food, usually by AMD AMD mill grinding, pneumatic conveying, classifier ancillary to complete. Materials smash very fine particle size, may indicate that the characteristics of the unexpected, but it also brings more issues, such as electrostatic adsorption, the mobility of poor materials, smashing the energy consumption, increase the cost of production, the processing operation of relatively large, these adverse effects can take different Methods to overcome (such as changes in feed processing).
     AMD smash through the material impact of the collision, shearing, grinding, and other means of dispersion. Squeeze the traditional crush of ultrafine grinding method can not be used to smash, otherwise they will have granulation effect. Choice smash methods, materials, subject to the crushing nature of the claim and determined than the smash, smash the materials were especially physical and chemical properties of a great decision, which the hardness of materials and more leads to the breakdown of status, hard and brittle material, the impact is very effective; The right medicine timber grinding and shearing method is better. In fact, any kind of grinder is not a simple rationale of a mill, are generally two or more arguments grinder to crush together, such as jet mill is the mutual impact and materials to smash the collision; High-speed impact mill is the impact and shear from the crush; Vibration of grinding, mixing and ball mill grinding mill was the main justification grinding, impact and shear; colloidal mills and the process mainly through high-speed rotation of the grinding mill with fixed by the relative movement of the strong shear, friction, impact and so on.

     2. AMD used to smash equipment
     2.1 mill mechanical impact smash highly efficient than the smash, simple structure, functioning and stability, suitable, the hardness of materials such grinder to crush not only the impact and friction with two smash, but also a jet mill, powders impact mill products because the high-speed operation, in order to generate Wear, in addition to heat, the crush of thermosensitive material Zhuang intended to take appropriate measures. Taizhou City, Zhejiang Lai special equipment to smash a series of factory production of wind mill increase transportation of materials, heat good effect, smashing a lower temperature region, can be used for certain thermosensitive material smash-chuan.

     2.2 jet mill is superheated steam or compressed air through the nozzle high supersonic airflow turbulence as the vector particles, particle and particle or particles between a fixed plate and between the impact of the extrusion, friction and shear, and thus achieve the purpose smash. With ordinary mechanical impact of AMD grinder than jet mill products can be crushed very detailed, a more narrow particle size distribution, particle size more uniform; Because of gas expansion in the nozzle can be cool, smashing process is not associated with the heat, so to crush a low temperature. Liu Yu of the low melting point and thermosensitive material AMD smash particularly important. But there are also a problem: the high cost of equipment manufacturers, a one-time investment, high energy consumption, energy Lichuan rate of only about 2%, as that method to smash several times higher than the other, so much powder processing costs, which makes it in this area by the use of certain restrictions: at the same time , it is difficult to achieve sub-micron products smash.

     2.3 General for ultrafine grinding ball mill is the traditional equipment, their characteristics than the smash, simple structure, mechanical reliability, easy to wear inspection and replacement parts, process maturity, adaptability, product size small. But size products to achieve 201 μ m, low efficiency, energy, long processing times. For example, hundreds of pearls to wear head to 10 hours.
     2.4 vibrating mill is grinding vibration Spring Mill organism support from the main block with its eccentric vibration when running through the media and materials from vibration, to crush materials, characterized by high dielectric filling degree, the role of unit time high frequency (frequency of the impact of the Mill 4 -- five times), hence its high efficient than ordinary Mill 10-20 times, and several times lower than the energy. By adjusting the vibration amplitude, frequency, types of media. Vibration mill product average particle size up to 2-3 μ m, the more brittle material can be relatively easy sub-micron products. Through the practice in recent years, increasing attention vibrating mill, the reason for this is that certain materials vibration mill products can achieve sub-micron particle size class, while strong mechanical and chemical effects, and simple structure, low energy consumption, high-efficiency mills, easy to industrial-scale production.

     2.5 mixing in ball mill grinding is developed on the basis, compared with the General Mill, stirred mill using high speed and high dielectric filling rate of medium and small size, was a high power density, fine grinding of materials greatly shorten the time, AMD is the highest mill in energy utilization, promising species equipment. Stir processing mill in less than 20 μ m materials, greatly improving efficiency, the smallest average size of the finished product could reach several microns. The high power density (high speed) can be used for mixing mill largest micron particle size is less than the following products, paints, ceramics, paper, paint, chemical products has been successful. At high power density stirred mill in a large-scale industrial application dealing with the high cost of the smallest and wear two problems. With the emergence of high-performance wear-resistant materials, I believe these issues can be resolved.

     3. AMD smash Chinese medicine processing technology in the application
     AMD 3.1 smash in the Chinese medicine processing advantages of Chinese medicine ultrafine grinding, mainly referring to the current micro-cell crush. "Micro-cells crush" refers to the ingredients of animal and plant cells broken for the purpose of crushing operations, using modern ultrafine grinding technology in the fine ingredients of the general conditions of the broken rate of 95%. Broken cell medicine, demonstrated the following advantages:

     (1) increase drug absorption rate, and improve their bioavailability.

     Drug powder particle size and impact of the structure is an important factor in drug absorption. AMD medicine after treatment, more subtle uniform particle size, surface area, pore increase of the rate of drugs in a better dispersion, dissolved in the gastrointestinal fluid, and litter and gastrointestinal membrane contact area increases, more susceptible to gastrointestinal absorption, regardless of the patch is topical or oral administration of capsules, the AMD smash after smaller doses can be used to the original efficacy, the Mineral medicine, the equivalent of water-insoluble substances, the AMD treatment, greatly reduced size, may be in its summary dissolution, absorption rate, improve its absorption capacity;

     (2) favorable biological activity of 10 reservations to improve efficacy.

     In superfine grinding process, the control may have overheated, even in low temperature conditions, wells and smash fast, reservations are heat resistant to the biological activity of the various components and nutrients, thereby improving efficacy as pearls, the traditional method of processing will destroy some of its components, and in low temperatures around -67 ° C under conditions of ultrafine grinding, can be compared to retain integrity active ingredients, enhance its role in delaying aging. Ganoderma is rich in amino acids and trace elements, with activated immune function, anti-tumor, anti-thrombotic effect, AMD smash, a more complete effect;

     (3) save raw materials, ease of application.

     AMD crush the medicine, smaller doses can be used, and effect of the original prescription, generic drugs, as AMD no longer can smash through extraction, processing and decocted, reducing the production aspect of the loss of the active ingredient, making maximum use of the raw materials, the technology Box 10 precious rare medicine smash and the fineness of the increase can improve the sense of ease of use on the other hand, because of AMD closed smash is no dust in the whole of the system, which can effectively avoid the pollution outside, microbial content and products to control dust.

     3.2 medicine study of ultrafine grinding Liu medicine in micro-crush cell research, the children of these ultrafine grinding equipment have in carrying out the exploration, and has made encouraging progress.

     Mill production due to low efficiency, and to crush a long time, in medicine in general crush AMD do not use. Use stirred mill right medicine to smash see AMD reported not many. Nanjing University of Technology and Engineering in Jiangsu Province powders Engineering Technology Research Center developed a highly efficient mixing Lc-grinding machine system, the aircraft interior with special agencies to prevent slurry bottom, not a "dead zone", the use of mechanical impact pulverizer right medicine cell micro-smash, particularly on the small brittle Carbohydrates and glial the crush of starch and dissociation, a demand shock velocity of 120 m / s, while the impact of the traditional mill impact velocity of 50 m / s around, so as to make use must be improved. Domestic currently in this respect, the relatively good unit: Wuxi light of the successful development of the University of mechanical shear AMD mill to be efficient fiber particles, with 10 successful soybean powder, bean powder production. Zhejiang will be too high precision machinery, turbine-grade and high-speed impact of combining micro-mill, develop a new generation of highly efficient energy-saving AMD CWJ grinder, the more successful solutions in the process of temperature rise smash, smash the particle size of 10 μ m. No size-tunable, narrow particle size distribution. The jet mill research, Nanjing University of Technology and Engineering in Jiangsu Province powders Engineering Technology Research Center of the supersonic airflow superfine grading system, multi-nozzle technology, fluidized bed technology and horizontal's points .

The system-level integration, a good functional classification of white, small size and homogeneous product, but is generally believed that the jet mill to crush fiber, toughness medicine more difficult, especially when operating in the crush of a relatively high speed airflow, the volatile drug taking, resulting in the loss pharmacodynamics So is only suitable for certain chemicals brittle micro-smash, smash or mineral medicine, and not to plant and animal medicine ultrafine grinding. In Chinese medicine ultrafine grinding, grinding vibration was most studied at home and abroad, the most extensive application of a device because the drug is expected to be grinding to sub-micron level, and high efficiency, is considered the best equipment. Former Germany, Japan on the flora and fauna of ultrafine grinding mill vibration more choice, China scholars in this regard has also been made a lot of achievements, Jinan times of the powder off Engineering Limited of a new third-generation vibration mill in a very short period of time to achieve the desired ingredients smash effect, and materials to enable Fine close Mixed (dispersion) effect. The company in Shandong Province K of the Industrial Research Institute, testing hundreds of Medicine ultrafine grinding, and the P-cyclodextrin inclusion and health ointment agent has made a useful attempt. Huazhong University of Science and Technology College of ultrafine grinding technology in the field after years of study, developed with independent intellectual property rights of ultrafine grinding equipment, including cryogenic grinding vibration equipment for the various types of traditional Chinese medicine to smash AMD micron, submicron powders ideal medicine equipment.

The equipment is from abroad vibration mill on the latest technology, Saikawa air spring damping, cryogenic environment which attracted the mill developed by mechanical refrigeration and double liquid nitrogen cryogenic refrigeration technology, and to use cold cycle, with high efficiency, cooling faster, less liquid nitrogen consumption, performance on the advantages of working temperature -150 ° C at room temperature continuously tunable, if not using liquid nitrogen can be -40 ° C at room temperature for the hospital has been working with the Hubei Provincial Research Institute of Chinese Medicine and a pharmaceutical factory, were hundreds of Chinese medicine ultrafine grinding, the results were more successful. In the Chinese medicine industry has good prospect.

     4. AMD smash in powder processing of tea
     Powder tea processing technology is the "Eighth Five-Year" period, China Academy of Agricultural Sciences Institute of tea development of the new tea processing technology, the types of green tea powder, black powder, oolong tea powder is widely used in food added, and "tea" as a "Drinking Tea for." The current application is the most extensive green tea powder, the key processing technology: First, the raw materials used leaf-green means green color processed into the dry tea Greenfield; Two ultrafine grinding technology is used, will smash into 300 heads of tea below about 60 μ m fine powder, and maintain the original color of tea. Powder tea because very fine granularity, in addition to food, eating in the population will not have any sense of size, it will enable both rich tea in food nutrition and health component, the original and to abandon the use of cellulose, but also gives a natural green food, the equivalent to adding a green pigment, shape as a special style tea food.
AMD green tea powder used by the green means First, add green leaf; The use of two-way finished steaming, Cui produce the color green steamed dried green tea.

Ultrafine powder processing equipment is the key to AMD LF-mill group, the tea particles spiral into the mouth feed grinding room, was crushed by the high-speed impact and shear, but also by the high frequency vibration Eddy was crushed. After smashing the powder in vacuum under cross triage classification of the sleeve into the room. The classification round of high-speed rotation, while the powder aerodynamic and centrifugal force role. When the centrifugal force> air power, also larger than the powder particle size classification requirements of fine silt, that is left out of the sleeve to return to smash Room smash, smash qualified powder at the aerodynamic> centrifugal force by force, the aggregate after the pipeline from the auxiliary was collected after a tea Supermicropowder finished.

     5. CONCLUSION
     Medicine cell micro-crush, could increase drug absorption rate, and improve their bioavailability; To retain active ingredients of cattle and improve efficacy; Save raw materials, ease of application. In all of ultrafine grinding equipment, vibration mill because of the possible effective drug to smash sub-micron level, is considered the best medicine for ultrafine grinding, the most promising devices. Medicine smash process temperature is a problem, use of a cryogenic cooling device will smash the crush of more mature technology.